Нонсенс-мутации у эукариот

Аннотация

Нонсенс-мутации представляют собой мутации, в результате которых появляется стоп-кодон. В то время как продолжает оставаться общепринятым рассмотрение этих мутаций как одних из самых вредных, приводящих к преждевременной терминации синтеза белка на рибосоме и, как следствие, к возникновению дефектного полипептида, накапливаются данные, согласно которым не все нонсенс-мутации вредны. Также существуют молекулярные механизмы, которые позволяют нивелировать потенциальное неблагоприятное воздействие данных мутаций. В представленном обзоре рассмотрены актуальные сведения о нонсенс-мутациях в геномах эукариот, характеристиках таковых мутаций и молекулярных механизмах предотвращения или смягчения их неблагоприятных эффектов.

Благодарности

Автор выражает благодарность Игорю Игоревичу Адамейко, Ольге Владимировне Черченко, Екатерине Юрьевне Царёвой, Эвелине Ильиничне Никельшпарг, Ивану Владимировичу Кулаковскому, а также Борису Романовичу Петрову за ценные комментарии.

Конфликт интересов

Автор заявляет об отсутствии конфликта интересов.

Соблюдение этических норм

Настоящая статья не содержит описания выполненных автором исследований с участием людей или использованием животных в качестве объектов.

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