БИОХИМИЯ, 2021, том 86, вып. 9, с. 1254–1264

УДК 577.1

Путешествие информосом во времени: ранняя концепция мРНК в контексте современных представлений об мРНП

Обзор

© 2021 П.В. Иванов 1,2,3pivanov@rics.bwh.harvard.edu

1 Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital, Boston, Massachusetts, 02115 USA

2 Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02115 USA

3 Harvard Medical School Initiative for RNA Medicine, Harvard University, Boston, Massachusetts, 02115 USA

Поступила в редакцию 27.05.2021
После доработки 09.07.2021
Принята к публикации 12.07.2021

DOI: 10.31857/S0320972521090025

КЛЮЧЕВЫЕ СЛОВА: информосомы, мРНК, рибонуклеопротеины, мРНП, РНК-гранулы, биосинтез белка.

Аннотация

На всём протяжении своего жизненного цикла матричная РНК (мРНК) существует в составе комплексов с белками. Впервые мРНК-содержащие частицы нерибосомной природы, называемые информосомами, были обнаружены в цитоплазматическом экстракте эмбрионов рыб сотрудниками лаборатории Александра Спирина, а позднее эти частицы были описаны и в живых клетках. Со временем были открыты и охарактеризованы и другие цитоплазматические, а также ядерные, мРНК-содержащие рибонуклеопротеины (мРНП). Несмотря на различия во внутриклеточной локализации, структуре и функциях, эти мРНП тем не менее обладают многими общими чертами, характерными также для информосом. В настоящем мини-обзоре рассматривается история открытия информосом, их характеристики и предполагаемые функции, а также их возможное родство с другими мРНП.

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Финансирование

Работа не была финансирована какими-либо фондами или проектами.

Благодарности

Павел Иванов выражает благодарность сотрудникам его лаборатории и доктору Claire Riggs за помощь в редактировании статьи.

Конфликт интересов

Автор заявляет об отсутствии конфликта интересов в финансовой или какой-либо иной сфере.

Соблюдение этических норм

Настоящая статья не содержит описания каких-либо исследований с участием людей или животных в качестве объектов, выполненных автором.

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