БИОХИМИЯ, 2021, том 86, вып. 8, с. 1149–1159

УДК 577.323.55

Свойства и функции мотива А‑минор, наиболее распространенного мотива структуры РНК

Обзор

© 2021 Е.Ф. Баулин 1,2baulin@lpm.org.ru

1 Институт математических проблем биологии РАН – филиал ИПМ им. М.В. Келдыша РАН, 142290 Пущино, Московская обл., Россия

2 Московский физико-технический институт (национальный исследовательский университет), 141701 Долгопрудный, Московская обл., Россия

Поступила в редакцию 01.05.2021
После доработки 13.06.2021
Принята к публикации 13.06.2021

DOI: 10.31857/S0320972521080078

КЛЮЧЕВЫЕ СЛОВА: структура РНК, третичный мотив, А-минор взаимодействие, мотив А-минор, А-патч.

Аннотация

Мотивы А-минор – это мотивы третичной структуры РНК, как правило состоящие из канонического спаривания оснований и основания аденина, образующего водородные связи с нуклеотидами спаривания со стороны малой бороздки. Мотивы А-минор являются одним из самых распространенных типов третичных взаимодействий в известных структурах РНК, сравнимым по частоте с неканоническими спариваниями оснований. Они часто обнаруживаются в функционально важных участках молекул некодирующих РНК и в том числе играют одну из центральных ролей в процессе синтеза белка. В данном обзоре рассматриваются локальные особенности геометрии А-миноров, трудности их разметки в известных пространственных структурах РНК, различия их структурного окружения и часто встречающиеся комотивы, а также разнообразные функции, выполняемые А-минорами во множестве внутриклеточных процессов.

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Финансирование

Работа не была финансирована какими-либо фондами или проектами.

Конфликт интересов

Авторы заявляют об отсутствии конфликта интересов.

Соблюдение этических норм

Настоящий обзор не содержит описания каких-либо исследований с участием людей или животных в качестве объектов.

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