Рецепторные функции семафорина 4D

Мини-обзор

«Институт экологии и генетики микроорганизмов Уральского отделения Российской академии наук» – филиал ПФИЦ УрО РАН, 614081 Пермь, Россия; электронная почта: ibis_07@mail.ru

Поступила в редакцию 04.04.2019
После доработки 15.05.2019
Принята к публикации 01.06.2019

DOI: 10.1134/S0320972519090045

КЛЮЧЕВЫЕ СЛОВА: мембранный Sema4D, Т-лимфоциты, В-лимфоциты, NK-клетки, нейтрофилы, опухолевые клетки.

Аннотация

Семафорин 4D (Sema4D) — многофункциональная молекула, которая широко представлена в организме и играет важную роль в контроле многих физиологических и патологических процессов, включая иммунорегуляцию, нейрогенез, ангиогенез, опухолевую прогрессию. Он был впервые описан почти 30 лет назад, и с тех пор активно изучается. Однако исследования регуляторной активности Sema4D, за редким исключением, исходят из того, что семафорин — это лиганд, реализующий свои эффекты через специфические рецепторы, плексины и CD72, а основные мишени действия Sema4D в различных тканях — клетки, несущие эти рецепторы на мембране. В настоящем обзоре приведен анализ данных, указывающих на наличие альтернативного способа участия Sema4D в регуляции: этот способ предполагает функционирование мембранного семафорина в качестве рецептора, проводящего сигнал в клетку, на которой экспрессирован. Обсуждаются механизмы сигнализации через мембранный Sema4D и их вклад в Sema4D-зависимую регуляцию клеточных функций.

Текст статьи

Финансирование

Исследование выполнено при финансовой поддержке Российского фонда фундаментальных исследований (проект № 19-015-00379) и в рамках государственного задания № 01201353248.

Конфликт интересов

Конфликт интересов в финансовой или какой-либо иной сфере отсутствует.

Соблюдение этических норм

Настоящая статья не содержит описания выполненных авторами исследований с участием людей или использованием животных в качестве объектов.

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