БИОХИМИЯ, 2019, том 84, вып. 3, с. 343–353

УДК 611.018.2

Внеклеточный матрикс в регуляции дифференцировки стволовых клеток

Обзор

© 2019 Е.С. Новоселецкая 1,2, О.А. Григорьева 1, А.Ю. Ефименко 1,2*, Н.И. Калинина 2

1 Институт регенеративной медицины, Медицинский научно-образовательный центр, Московский государственный университет им. М.В. Ломоносова, 119991 Москва, Россия; электронная почта: efimenkoan@gmail.com

2 Московский государственный университет им. М.В. Ломоносова, факультет фундаментальной медицины, 119991 Москва, Россия

Поступила в редакцию 09.11.2018
После доработки 06.12.2018
Принята к публикации 06.12.2018

DOI: 10.1134/S0320972519030059

КЛЮЧЕВЫЕ СЛОВА: внеклеточный матрикс, стволовые клетки, дифференцировка, ниша стволовой клетки, внеклеточные везикулы, децеллюляризация.

Аннотация

Белки внеклеточного матрикса (ВКМ) заполняют пространство между клетками в многоклеточных организмах, создавая структуру органов и тканей. Механические свойства ВКМ хорошо изучены. В настоящее время интенсивно исследуется роль отдельных компонентов ВКМ и трехмерных тканеспецифичных матриксов в регуляции функциональной активности клеток, их пролиферации, миграции, приобретении специализированного фенотипа и его поддержании. В данном обзоре рассмотрены основные структурные белки, ферменты и внеклеточные везикулы, входящие в состав ВКМ; приведены данные об участии компонентов ВКМ в регуляции дифференцировки и самоподдержания стволовых клеток; рассмотрены подходы к моделированию микроокружения стволовых клеток с помощью децеллюляризированного ВКМ.

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* Адресат для корреспонденции.

Финансирование

Работа выполнена при поддержке РНФ (грант № 14-15-00439; исследование роли внеклеточных везикул и взаимодействия ВКМ с МСК) и Минобрнауки России (грант № MK-2422.2017.7; использование децеллюляризации для изучения роли ВКМ).

Конфликт интересов

Авторы заявляют об отсутствии конфликта интересов.

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