TRPA1 канал — регулятор нейрогенного воспаления и боли: структура, функция, роль в патофизиологии, терапевтический потенциал лигандов

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Финансирование

Работа поддержана РНФ (грант 16-15-00167).

Конфликт интересов

Авторы заявляют об отсутствии конфликта интересов.

Соблюдение этических норм

Настоящая статья не содержит описания каких-либо исследований с использованием людей и животных в качестве объектов.

Список литературы

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63. Sadofsky, L.R., Boa, A.N., Maher, S.A., Birrell, M.A., Belvisi, M.G., and Morice, A.H. (2011) TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids, Pharmacol. Res., 63, 30–36.

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79. Motter, A.L., and Ahern, G.P. (2012) TRPA1 is a polyunsaturated fatty acid sensor in mammals, PLoS One, 7, e38439.

80. Takahashi, N., Mizuno, Y., Kozai, D., Yamamoto, S., Kiyonaka, S., Shibata, T., Uchida, K., and Mori, Y. (2008) Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators, Channels (Austin), 2, 287–298.

81. Matta, J.A., Cornett, P.M., Miyares, R.L., Abe, K., Sahibzada, N., and Ahern, G.P. (2008) General anesthetics activate a nociceptive ion channel to enhance pain and inflammation, Proc. Natl. Acad. Sci. USA, 105, 8784–8789.

82. Maher, M., Ao, H., Banke, T., Nasser, N., Wu, N.T., Breitenbucher, J.G., Chaplan, S.R., and Wickenden, A.D. (2008) Activation of TRPA1 by farnesyl thiosalicylic acid, Mol. Pharmacol., 73, 1225–1234.

83. Liu, K., Samuel, M., Ho, M., Harrison, R.K., and Paslay, J.W. (2010) NPPB structure-specifically activates TRPA1 channels, Biochem. Pharmacol., 80, 113–121.

84. Karashima, Y., Damann, N., Prenen, J., Talavera, K., Segal, A., Voets, T., and Nilius, B. (2007) Bimodal action of menthol on the transient receptor potential channel TRPA1, J. Neurosci., 27, 9874–9884.

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87. Andersson, D.A., Gentry, C., and Bevan, S. (2012) TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide, PLoS One, 7, e46917.

88. Eberhardt, M., Dux, M., Namer, B., Miljkovic, J., Cordasic, N., Will, C., Kichko, T.I., de la Roche, J., Fischer, M., Suarez, S.A., Bikiel, D., Dorsch, K., Leffler, A., Babes, A., Lampert, A., Lennerz, J.K., Jacobi, J., Marti, M.A., Doctorovich, F., Hogestatt, E.D., Zygmunt, P.M., Ivanovic-Burmazovic, I., Messlinger, K., Reeh, P., and Filipovic, M.R. (2014) H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway, Nat. Commun., 5, 4381.

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90. Hu, H., Bandell, M., Petrus, M.J., Zhu, M.X., and Patapoutian, A. (2009) Zinc activates damage-sensing TRPA1 ion channels, Nat. Chem. Biol., 5, 183–190.

91. Wang, Y.Y., Chang, R.B., Waters, H.N., McKemy, D.D., and Liman, E.R. (2008) The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions, J. Biol. Chem., 283, 32691–32703.

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93. Hasan, R., Leeson-Payne, A.T.S., Jaggar, J.H., and Zhang, X. (2017) Calmodulin is responsible for Ca2+-dependent regulation of TRPA1 Channels, Sci. Rep., 7, 45098.

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95. Alpizar, Y.A., Gees, M., Sanchez, A., Apetrei, A., Voets, T., Nilius, B., and Talavera, K. (2013) Bimodal effects of cinnamaldehyde and camphor on mouse TRPA1, Pflugers. Arch., 465, 853–864.

96. Cavanaugh, E.J., Simkin, D., and Kim, D. (2008) Activation of transient receptor potential A1 channels by mustard oil, tetrahydrocannabinol and Ca2+ reveals different functional channel states, Neuroscience, 154, 1467–1476.

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