БИОХИМИЯ, 2022, том 87, вып. 6, с. 780–793
УДК 62.018.2:017.12
Т‑лимфоциты как мишени для SARS‑CoV‑2
Обзор
ФГБУН Пермский федеральный исследовательский центр УрО РАН, «Институт экологии и генетики микроорганизмов УрО РАН», 614081 Пермь, Россия
Поступила в редакцию 19.04.2022
После доработки 17.05.2022
Принята к публикации 17.05.2022
DOI: 10.31857/S0320972522060069
КЛЮЧЕВЫЕ СЛОВА: SARS‑CoV‑2, T‑лимфоциты, ACE2, CD147, Treg.
Аннотация
Несмотря на многочисленные данные об отсутствии или слабой экспрессии Т‑клетками главного функционального рецептора SARS‑CoV‑2, ангиотензин I‑превращающего фермента 2 (ACE2), последние данные литературы демонстрируют способность нового коронавируса эффективно инфицировать Т‑лимфоциты. Обзор посвящён анализу этих работ: он рассматривает альтернативные (АСЕ2-независимые) пути инфицирования клеток, определяет Т‑клеточные субпопуляции, служащие наиболее вероятными мишенями SARS‑CoV‑2, обсуждает формат взаимодействия вируса с клеткой, включая как инфекционные, так и неинфекционные механизмы регуляции Т‑лимфоцитов, а также оценивает роль вирус-зависимого поражения Т‑лимфоцитов в патогенезе COVID‑19. Особое внимание уделено регуляторным Т‑клеткам, как потенциальным мишеням SARS‑CoV‑2, а также возможному участию экзосом в регуляции чувствительности к вирусу Т‑лимфоцитов, присутствующих в периферических тканях.
Текст статьи
Сноски
* Адресат для корреспонденции.
Финансирование
Исследование выполнено в рамках государственного задания (тема госрегистрации № АААА‑А19‑119112290007‑7).
Конфликт интересов
Автор заявляет об отсутствии конфликта интересов.
Соблюдение этических норм
Настоящая статья не содержит описания каких-либо исследований с участием людей или животных в качестве объектов.
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