БИОХИМИЯ, 2020, том 85, вып. 10, с. 1323–1330

УДК 577.24

Программируемая гибель клеток: исторические заметки из России

Мини-обзор

© 2020 Б. Животовский 1,2

Московский государственный университет имени М.В. Ломоносова, факультет фундаментальной медицины, 119991 Москва, Россия

Институт медицины окружающей среды, Каролинский институт, Стокгольм, Швеция; электронная почта: boris.zhivotovsky@ki.se

Поступила в редакцию 12.07.2020
После доработки 12.07.2020
Принята к публикации 16.07.2020

DOI: 10.31857/S0320972520100012

КЛЮЧЕВЫЕ СЛОВА: апоптоз, радиация, митохондрии, нуклеазы, протеазы.

Аннотация

Исследование механизмов гибели клеток – одна из наиболее быстро развивающихся областей современной биомедицины. Особый интерес к этой проблеме возник в 1972 г. после опубликования статьи Kerr, Wyllie и Currie, в которой апоптоз, один из типов гибели клеток, впервые был рассмотрен как базовый биологический феномен, регулирующий гомеостаз тканей. Несколько российских групп, занимавшихся изучением механизмов индуцируемой радиацией гибели клеток, обратили внимание на схожесть между этими двумя механизмами. По некоторым объективным причинам эти работы долгое время нe были доступны мировой общественности. В настоящем введении предпринята попытка восстановить цепь событий минувших дней.

Финансирование

Работа выполнена при финансовой поддержке гранта РНФ (19-15-00125). Работа лабораторий также поддерживается грантами РФФИ (18-29-09005), Шведского (190345) и Стокгольмского (181301) противораковых фондов.

Конфликт интересов

Автор заявляет об отсутствии конфликта интересов.

Соблюдение этических норм

Настоящая работа не содержит описания выполненных авторами исследований с участием людей или использованием животных в качестве объектов.

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